In Perception, Eric McCormack plays Dr. Geoffrey Pierce, an eccentric neuroscientist who uses his unique outlook and expertise to help the federal government crack difficult cases. Pierce's intimate knowledge of human behavior and masterful understanding of the mind are matched by his equally odd and imaginative view of the world. Rachael Leigh Cook co-stars as FBI agent Kate Rossi, Pierce's former student and the person responsible for recruiting him to work for the government. Arjay Smith plays Max Lewicki, Pierce's teaching assistant who has spent nine years at college. Kelly Rowan is Natalie Vincent, Pierce's best friend and every bit his intellectual equal.
When renowned neuroscientist Landon Jennings is found dead, Moretti and Pierce must figure out how someone could have gained access to his impenetrable study in order to kill him. Lewicki finds himself with twice the work when Pierce’s father James moves in with them.
Moretti calls on Pierce to examine Elena Douglas, a woman who has confessed to murder and claims to be possessed by the Devil. Meanwhile, Donnie and Moretti’s wedding plans hit a bump in the road.
After a young victim with a developmental disorder is taken hostage in a bank robbery, Moretti brings in Pierce to interview the boy. When they finally track down the culprits, they discover the case is about much more than money. Meanwhile, Pierce’s estranged father James pays him a visit.
When a prosecutor mysteriously drops dead in the middle of a courtroom, Pierce and Moretti go on the hunt for a killer. Meanwhile, Moretti and Donnie make some decisions about their future.
Dr. Daniel Pierce’s picture-perfect new life in Paris is suddenly turned upside down after he is approached by the FBI legat to help with a dangerous international case. Meanwhile, his assistant Max Lewicki and Dean Paul Haley plot to get Pierce to return to Chicago.