When a brilliant and driven neurosurgeon’s career is cut short, she turns her unrivaled medical skills toward solving murders. Every body has a story to tell and Dr. Megan Hunt will find out what it is.
Megan's father's exhumation uncovers more questions about what she always believed was a suicide, and her mother suggests she examine his patient files for clues about his death and that of a patient.
An inmate violently escapes from a prison transport van and becomes a dangerous fugitive on the run in Philadelphia. Soon another man turns up dead - who's revealed to be a witness in the escaped prisoner's murder trial. Megan must continue to search for the truth in the original case when the accused murderer shows up and pleads with her that he is innocent and being framed.
When a plane crashes in Philadelphia due to a gunman opening fire while aloft, the entire team of Megan, Kate, Tommy, Adam, Curtis, Ethan, Riley and Stafford must go into disaster mode. Since the crash hits the city's main power grid, Megan must conduct autopsies on the victims during frequent blackouts, but then one of the bodies goes missing. Meanwhile, Tommy and Riley are in a serious car accident while trying to investigate.