Jessica Day is an offbeat and adorable girl in her late 20s who, after a bad breakup, moves in with three single guys. Goofy, positive, vulnerable and honest to a fault, Jess has faith in people, even when she shouldn't. Although she's dorky and awkward, she's comfortable in her own skin. More prone to friendships with women, she's not used to hanging with the boys--especially at home.
When Jess learns that a friend is pregnant, both she and Cece panic that time is running out for them to have children. Meanwhile, Schmidt seeks advice on how to please Emma, and Nick and Winston visit the zoo to find inspiration for Nick's zombie-themed novel.
Jess invites her divorced Mom and Dad over for Thanksgiving dinner and enlists Nick and Cece to help her with a "Parent Trap" to reunite them. Meanwhile, Schmidt's cousin, Big Schmidt, visits, and Winston manipulates them into an escalating battle to prove their manhood.
As Jess' job search kicks into high gear, the guys fear her time of the month is also affecting their physical and psychological well-being. Meanwhile, Schmidt begins a "50 Shades of Grey"-type of relationship with his corporate boss, and Nick gains wisdom from an unlikely, hands-on (and mute) source.
Jess gets a job as a zombie at a haunted house, but is more frightened of her changing feelings towards Sam. Schmidt and Cece are perfectly matched in the costumes they're wearing, while Winston and Shelby are worlds apart in theirs. Nick gets a visit from a former college crush who shows her affection in a scary way.