The show follows the journey of a time traveler, Cole, from the post-apocalyptic future. Using a dangerous and untested method of time travel, Cole arrives in the present day on a mission to locate and eradicate the source of a deadly plague that will eventually decimate 93.6% of the human race. Will Cole be able to save the fate of mankind or is mankind bound by fate? Taking place in the ravaged future of 2043 and the present day, 12 Monkeys explores themes of destiny, fate, love and the possibility of second chances.
27 years after a virus wipes out most of humanity, scientists send a man back to 2015 to stop the plague from ever happening. Cole's only lead is a virologist, who knows the dangerous source of the outbreak.