In Perception, Eric McCormack plays Dr. Geoffrey Pierce, an eccentric neuroscientist who uses his unique outlook and expertise to help the federal government crack difficult cases. Pierce's intimate knowledge of human behavior and masterful understanding of the mind are matched by his equally odd and imaginative view of the world. Rachael Leigh Cook co-stars as FBI agent Kate Rossi, Pierce's former student and the person responsible for recruiting him to work for the government. Arjay Smith plays Max Lewicki, Pierce's teaching assistant who has spent nine years at college. Kelly Rowan is Natalie Vincent, Pierce's best friend and every bit his intellectual equal.
When a series of bizarre public murders occur, Pierce realizes that the killer is trying to send a message about inattentional blindness, but Donnie doubts this theory. But Pierce has a trick up his sleeve that can prove his point, and they must scramble to piece together the clues before the clever killer can make any more examples out of innocent victims.
Pierce and Moretti take on an extraterrestrial case when a woman reports that aliens have abducted her husband. When Pierce and Moretti arrive to investigate, however, they make a startling discovery. Meanwhile, things heat up between Pierce and his real-life girlfriend, Caroline, but his relationship could be jeopardized if he can't get his imaginary girlfriend, Natalie, out of his mind.
FBI Agent Kate Moretti asks Dr. Daniel Pierce to determine the mental competency of a man being retried for murder. But the trial takes a shocking and unexpected turn when Pierce’s findings question whether the person standing trial is the same person he was six years ago. Meanwhile, Moretti is unpleasantly surprised to discover that the Assistant U.S. Attorney prosecuting the case is her soon-to-be-ex-husband Donnie Ryan.